Title : MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation.

Pub. Date : 2015 Aug 18

PMID : 26240347






3 Functional Relationships(s)
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1 MTMR3 decreased PRR-induced phosphatidylinositol 3-phosphate (PtdIns3P) and autophagy levels, thereby increasing PRR-induced caspase-1 activation, autocrine IL-1beta secretion, NFkappaB signaling, and, ultimately, overall cytokine secretion. phosphatidylinositol 3-phosphate myotubularin related protein 3 Homo sapiens
2 MTMR3 decreased PRR-induced phosphatidylinositol 3-phosphate (PtdIns3P) and autophagy levels, thereby increasing PRR-induced caspase-1 activation, autocrine IL-1beta secretion, NFkappaB signaling, and, ultimately, overall cytokine secretion. phosphatidylinositol 3-phosphate myotubularin related protein 3 Homo sapiens
3 Macrophages from rs713875 CC IBD risk carriers demonstrated increased MTMR3 expression and, in turn, decreased PRR-induced PtdIns3P and autophagy and increased PRR-induced caspase-1 activation, signaling, and cytokine secretion. phosphatidylinositol 3-phosphate myotubularin related protein 3 Homo sapiens