Pub. Date : 1989 Nov 28
PMID : 2606156
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vitro, THA inhibits acetylcholinesterase (AChE) (IC50 = 223 nM) and blocks [3H]AFDX-116 (M2) and [3H]telenzepine (M1) binding (IC50 s of 1.5 and 9.1 microM respectively). | Tacrine | acetylcholinesterase | Rattus norvegicus |
| 2 | We conclude that brain AChE inhibition by THA is sufficient to explain its purported therapeutic activity in Alzheimer"s disease and that its favorable brain/plasma distribution in vivo may account for its central cholinergic action without inducing the severe peripheral cholinergic effects typically seen with other AChE inhibitors. | Tacrine | acetylcholinesterase | Rattus norvegicus |