Title : BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells.

Pub. Date : 2015 May 6

PMID : 25944566






1 Functional Relationships(s)
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1 Here we demonstrate that bromodomain inhibitors (BETi), JQ1, I-BET151, I-BET762, exert potent anti-tumour activity against primary and established OS cell lines, mediated by inhibition of BRD4. beti bromodomain containing 4 Homo sapiens