Title : Relative substrate activities of structurally related pteridine, quinazoline, and pyrimidine analogs for mouse liver folylpolyglutamate synthetase.

Pub. Date : 1989 Nov

PMID : 2586490






1 Functional Relationships(s)
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1 It was also inferred from these observations that the volume within the active site of FPGS above/below the pyrazine ring or near the 10-position of folate derivatives are regions of limited bulk tolerance; binding of folate analogs with substituents at these positions probably distorts the active site. Pyrazines folylpolyglutamyl synthetase Mus musculus