Pub. Date : 2015
PMID : 25789479
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytoplasmic PELP1 and ERRgamma protect human mammary epithelial cells from Tam-induced cell death. | Tamoxifen | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 2 | Prior studies have shown that cytoplasmic proline, glutamic acid and leucine rich protein 1 (PELP1) promotes Tam resistance in breast cancer cell lines. | Proline | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 3 | Prior studies have shown that cytoplasmic proline, glutamic acid and leucine rich protein 1 (PELP1) promotes Tam resistance in breast cancer cell lines. | Tamoxifen | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 4 | In vitro, immortalized HMECs expressing a nuclear localization signal (NLS) mutant of PELP1 (PELP1-cyto) were resistant to Tam-induced death. | Tamoxifen | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 5 | In vitro, immortalized HMECs expressing a nuclear localization signal (NLS) mutant of PELP1 (PELP1-cyto) were resistant to Tam-induced death. | Tamoxifen | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 6 | Expression of PELP1-cyto and ERRgamma reduced Tam-induced LC3-II accumulation, and knockdown of ERRgamma increased LC3-II levels in response to Tam. | Tamoxifen | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 7 | Our data indicate that cytoplasmic PELP1 induces signaling pathways that converge on ERRgamma to promote cell survival in the presence of Tam. | Tamoxifen | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 8 | These data suggest that PELP1 localization and/or ERRgamma activation could be developed as tissue biomarkers for Tam responsiveness. | Tamoxifen | proline, glutamate and leucine rich protein 1 | Homo sapiens |