Pub. Date : 2015
PMID : 25700560
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SIRT5 regulation of ammonia-induced autophagy and mitophagy. | Ammonia | sirtuin 5 | Homo sapiens |
| 2 | In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle. | Ammonia | sirtuin 5 | Homo sapiens |
| 3 | In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle. | Urea | sirtuin 5 | Homo sapiens |
| 4 | To address the possibility that SIRT5 is involved in ammonia production also in nonliver cells, clones of human breast cancer cell lines MDA-MB-231 and mouse myoblast C2C12, overexpressing or silenced for SIRT5 were produced. | Ammonia | sirtuin 5 | Homo sapiens |
| 5 | Our results show that ammonia production increased in SIRT5-silenced and decreased in SIRT5-overexpressing cells. | Ammonia | sirtuin 5 | Homo sapiens |
| 6 | Our results show that ammonia production increased in SIRT5-silenced and decreased in SIRT5-overexpressing cells. | Ammonia | sirtuin 5 | Homo sapiens |
| 7 | We also obtained the same ammonia increase when using a new specific inhibitor of SIRT5 called MC3482. | Ammonia | sirtuin 5 | Homo sapiens |
| 8 | We also obtained the same ammonia increase when using a new specific inhibitor of SIRT5 called MC3482. | MC3482 | sirtuin 5 | Homo sapiens |
| 9 | SIRT5 regulates ammonia production by controlling glutamine metabolism. | Ammonia | sirtuin 5 | Homo sapiens |
| 10 | SIRT5 regulates ammonia production by controlling glutamine metabolism. | Glutamine | sirtuin 5 | Homo sapiens |
| 11 | In conclusion we propose that the role of SIRT5 in nonliver cells is to regulate ammonia production and ammonia-induced autophagy by regulating glutamine metabolism. | Ammonia | sirtuin 5 | Homo sapiens |
| 12 | In conclusion we propose that the role of SIRT5 in nonliver cells is to regulate ammonia production and ammonia-induced autophagy by regulating glutamine metabolism. | Ammonia | sirtuin 5 | Homo sapiens |
| 13 | In conclusion we propose that the role of SIRT5 in nonliver cells is to regulate ammonia production and ammonia-induced autophagy by regulating glutamine metabolism. | Glutamine | sirtuin 5 | Homo sapiens |