Pub. Date : 2015 Jul
PMID : 25695262
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of PAF-R, using the PAF-R agonist, 1-hexadecyl-2-N-methylcarbamoyl-3-glycerophosphocholine, induced an increase in the proliferation of B16-PAF-R cells compared with the B16-MSCV cells. | 1-hexadecyl-2-n-methylcarbamoyl-3-glycerophosphocholine | platelet activating factor receptor | Homo sapiens |
| 2 | Activation of PAF-R, using the PAF-R agonist, 1-hexadecyl-2-N-methylcarbamoyl-3-glycerophosphocholine, induced an increase in the proliferation of B16-PAF-R cells compared with the B16-MSCV cells. | 1-hexadecyl-2-n-methylcarbamoyl-3-glycerophosphocholine | platelet activating factor receptor | Homo sapiens |
| 3 | Activation of PAF-R, using the PAF-R agonist, 1-hexadecyl-2-N-methylcarbamoyl-3-glycerophosphocholine, induced an increase in the proliferation of B16-PAF-R cells compared with the B16-MSCV cells. | 1-hexadecyl-2-n-methylcarbamoyl-3-glycerophosphocholine | platelet activating factor receptor | Homo sapiens |
| 4 | In order to determine the underlying mechanism, flow cytometric analysis was used, which demonstrated a significant increase in the generation of reactive oxygen species (ROS) in the B16-PAF-R cells compared with the B16-MSCV cells, which enhanced apoptosis by BITC, as measured by increased caspase-3/7 luminescence. | Reactive Oxygen Species | platelet activating factor receptor | Homo sapiens |
| 5 | In order to determine the underlying mechanism, flow cytometric analysis was used, which demonstrated a significant increase in the generation of reactive oxygen species (ROS) in the B16-PAF-R cells compared with the B16-MSCV cells, which enhanced apoptosis by BITC, as measured by increased caspase-3/7 luminescence. | Reactive Oxygen Species | platelet activating factor receptor | Homo sapiens |
| 6 | Notably, the BITC-mediated decreased cell survival rate, increased ROS and increased apoptosis in the B16-PAF-R cells were significantly attenuated by the antioxidant, vitamin C, indicating ROS involvement. | Ascorbic Acid | platelet activating factor receptor | Homo sapiens |
| 7 | Notably, the BITC-mediated decreased cell survival rate, increased ROS and increased apoptosis in the B16-PAF-R cells were significantly attenuated by the antioxidant, vitamin C, indicating ROS involvement. | Reactive Oxygen Species | platelet activating factor receptor | Homo sapiens |