Pub. Date : 2015 Mar 1
PMID : 25678016
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Discovery and structure-activity relationship studies of N6-benzoyladenine derivatives as novel BRD4 inhibitors. | N6-benzoyladenine | bromodomain containing 4 | Homo sapiens |
| 2 | As a part of our continuing structural development studies of thalidomide to obtain a broad spectrum of biological modifiers based on the "multi-template" approach, in this work we focused on BRD4-inhibitory activity, and discovered that N6-benzoyladenine derivatives exhibit this activity. | N6-benzoyladenine | bromodomain containing 4 | Homo sapiens |
| 3 | Structure-activity relationship studies led to N6-(2,4,5-trimethoxybenzoyl)adenine (29), which exhibits potent BRD4 bromodomain1 inhibitory activity with an IC50 value of 0.427muM. | n6-(2,4,5-trimethoxybenzoyl)adenine | bromodomain containing 4 | Homo sapiens |
| 4 | N6-Benzoyladenine appears to be a new chemical scaffold for development of BRD4 inhibitors. | N6-benzoyladenine | bromodomain containing 4 | Homo sapiens |