Title : Time dependence of Li+ action on acetylcholinesterase activity in correlation with spontaneous quantal release of acetylcholine in rat diaphragm.

Pub. Date : 1989

PMID : 2552204






6 Functional Relationships(s)
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1 Incubation of diaphragm homogenate with NaCl caused initially a slight increase of AChE activity, reaching a plateau after 20 min. Sodium Chloride acetylcholinesterase Rattus norvegicus
2 Substitution of LiCl for NaCl produced an increase in AChE activity to a maximum, followed by a decrease to a minimum. Lithium Chloride acetylcholinesterase Rattus norvegicus
3 Substitution of LiCl for NaCl produced an increase in AChE activity to a maximum, followed by a decrease to a minimum. Sodium Chloride acetylcholinesterase Rattus norvegicus
4 During complete substitution of LiCl for NaCl, the maximum value of AChE activity coincided with the maximum m.e.p.p. Lithium Chloride acetylcholinesterase Rattus norvegicus
5 During complete substitution of LiCl for NaCl, the maximum value of AChE activity coincided with the maximum m.e.p.p. Sodium Chloride acetylcholinesterase Rattus norvegicus
6 The addition of prostigmine caused: a) blockade of AChE activity, and b) prostigmine concentration-dependent decrease of Fmax and/or disappearance of m.e.p.p.s from neuromuscular junctions treated with Li+. Neostigmine acetylcholinesterase Rattus norvegicus