Title : The effect of gamma interferon on interleukin 1 release of human monocytes. Dependence on the activating agent and correlation to the mRNA levels.

Pub. Date : 1989 Jun

PMID : 2544986






8 Functional Relationships(s)
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1 The effect of gamma interferon (IFN-gamma) on interleukin 1 (IL-1) production by human monocytes induced either by bacterial lipopolysaccharide (LPS) or silica dust was examined. Silicon Dioxide interferon gamma Homo sapiens
2 The effect of gamma interferon (IFN-gamma) on interleukin 1 (IL-1) production by human monocytes induced either by bacterial lipopolysaccharide (LPS) or silica dust was examined. Silicon Dioxide interleukin 1 beta Homo sapiens
3 In contrast to these data, IFN-gamma had a decreasing effect on IL-1 release by monocytes stimulated with silica dust; in monocyte cultures stimulated with a sub-optimal dose of silica (100 micrograms/ml), only minute amounts of biologically active IL-1 were released in the presence of IFN-gamma. Silicon Dioxide interferon gamma Homo sapiens
4 In contrast to these data, IFN-gamma had a decreasing effect on IL-1 release by monocytes stimulated with silica dust; in monocyte cultures stimulated with a sub-optimal dose of silica (100 micrograms/ml), only minute amounts of biologically active IL-1 were released in the presence of IFN-gamma. Silicon Dioxide interleukin 1 beta Homo sapiens
5 In contrast to these data, IFN-gamma had a decreasing effect on IL-1 release by monocytes stimulated with silica dust; in monocyte cultures stimulated with a sub-optimal dose of silica (100 micrograms/ml), only minute amounts of biologically active IL-1 were released in the presence of IFN-gamma. Silicon Dioxide interleukin 1 beta Homo sapiens
6 In contrast to these data, IFN-gamma had a decreasing effect on IL-1 release by monocytes stimulated with silica dust; in monocyte cultures stimulated with a sub-optimal dose of silica (100 micrograms/ml), only minute amounts of biologically active IL-1 were released in the presence of IFN-gamma. Silicon Dioxide interferon gamma Homo sapiens
7 In contrast, in silica-stimulated monocytes IFN-gamma reduced the steady-state levels of IL-1 beta mRNA. Silicon Dioxide interferon gamma Homo sapiens
8 In contrast, in silica-stimulated monocytes IFN-gamma reduced the steady-state levels of IL-1 beta mRNA. Silicon Dioxide interleukin 1 beta Homo sapiens