Title : Site-selective 8-chloroadenosine 3',5'-cyclic monophosphate inhibits transformation and transforming growth factor alpha production in Ki-ras-transformed rat fibroblasts.

Pub. Date : 1989 Jan 2

PMID : 2536620






17 Functional Relationships(s)
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1 Site-selective 8-chloroadenosine 3",5"-cyclic monophosphate inhibits transformation and transforming growth factor alpha production in Ki-ras-transformed rat fibroblasts. 8-chloro-cyclic adenosine monophosphate transforming growth factor alpha Rattus norvegicus
2 Site-selective 8-chloroadenosine 3",5"-cyclic monophosphate inhibits transformation and transforming growth factor alpha production in Ki-ras-transformed rat fibroblasts. 8-chloro-cyclic adenosine monophosphate KRAS proto-oncogene, GTPase Rattus norvegicus
3 A site-selective cAMP analog, 8-chloroadenosine 3",5"-cyclic monophosphate (8-Cl-cAMP), was demonstrated to be a potent inhibitor of both the monolayer and soft agar growth of normal rat kidney (NRK) fibroblasts that had been transformed with the v-Ki-ras oncogene or treated with transforming growth factor alpha (TGF alpha). 8-chloro-cyclic adenosine monophosphate KRAS proto-oncogene, GTPase Rattus norvegicus
4 A site-selective cAMP analog, 8-chloroadenosine 3",5"-cyclic monophosphate (8-Cl-cAMP), was demonstrated to be a potent inhibitor of both the monolayer and soft agar growth of normal rat kidney (NRK) fibroblasts that had been transformed with the v-Ki-ras oncogene or treated with transforming growth factor alpha (TGF alpha). 8-chloro-cyclic adenosine monophosphate transforming growth factor alpha Rattus norvegicus
5 A site-selective cAMP analog, 8-chloroadenosine 3",5"-cyclic monophosphate (8-Cl-cAMP), was demonstrated to be a potent inhibitor of both the monolayer and soft agar growth of normal rat kidney (NRK) fibroblasts that had been transformed with the v-Ki-ras oncogene or treated with transforming growth factor alpha (TGF alpha). 8-chloro-cyclic adenosine monophosphate transforming growth factor alpha Rattus norvegicus
6 A site-selective cAMP analog, 8-chloroadenosine 3",5"-cyclic monophosphate (8-Cl-cAMP), was demonstrated to be a potent inhibitor of both the monolayer and soft agar growth of normal rat kidney (NRK) fibroblasts that had been transformed with the v-Ki-ras oncogene or treated with transforming growth factor alpha (TGF alpha). 8-chloro-cyclic adenosine monophosphate KRAS proto-oncogene, GTPase Rattus norvegicus
7 A site-selective cAMP analog, 8-chloroadenosine 3",5"-cyclic monophosphate (8-Cl-cAMP), was demonstrated to be a potent inhibitor of both the monolayer and soft agar growth of normal rat kidney (NRK) fibroblasts that had been transformed with the v-Ki-ras oncogene or treated with transforming growth factor alpha (TGF alpha). 8-chloro-cyclic adenosine monophosphate transforming growth factor alpha Rattus norvegicus
8 A site-selective cAMP analog, 8-chloroadenosine 3",5"-cyclic monophosphate (8-Cl-cAMP), was demonstrated to be a potent inhibitor of both the monolayer and soft agar growth of normal rat kidney (NRK) fibroblasts that had been transformed with the v-Ki-ras oncogene or treated with transforming growth factor alpha (TGF alpha). 8-chloro-cyclic adenosine monophosphate transforming growth factor alpha Rattus norvegicus
9 A site-selective cAMP analog, 8-chloroadenosine 3",5"-cyclic monophosphate (8-Cl-cAMP), was demonstrated to be a potent inhibitor of both the monolayer and soft agar growth of normal rat kidney (NRK) fibroblasts that had been transformed with the v-Ki-ras oncogene or treated with transforming growth factor alpha (TGF alpha). 8-chloro-cyclic adenosine monophosphate KRAS proto-oncogene, GTPase Rattus norvegicus
10 A site-selective cAMP analog, 8-chloroadenosine 3",5"-cyclic monophosphate (8-Cl-cAMP), was demonstrated to be a potent inhibitor of both the monolayer and soft agar growth of normal rat kidney (NRK) fibroblasts that had been transformed with the v-Ki-ras oncogene or treated with transforming growth factor alpha (TGF alpha). 8-chloro-cyclic adenosine monophosphate transforming growth factor alpha Rattus norvegicus
11 A site-selective cAMP analog, 8-chloroadenosine 3",5"-cyclic monophosphate (8-Cl-cAMP), was demonstrated to be a potent inhibitor of both the monolayer and soft agar growth of normal rat kidney (NRK) fibroblasts that had been transformed with the v-Ki-ras oncogene or treated with transforming growth factor alpha (TGF alpha). 8-chloro-cyclic adenosine monophosphate transforming growth factor alpha Rattus norvegicus
12 These effects of 8-Cl-cAMP were linked to the cAMP analog"s selective modulation of the type I and type II cAMP-dependent protein kinase regulatory subunits, RI and RII, present in Ki-ras-transformed and TGF alpha-treated NRK cells. 8-chloro-cyclic adenosine monophosphate KRAS proto-oncogene, GTPase Rattus norvegicus
13 These effects of 8-Cl-cAMP were linked to the cAMP analog"s selective modulation of the type I and type II cAMP-dependent protein kinase regulatory subunits, RI and RII, present in Ki-ras-transformed and TGF alpha-treated NRK cells. 8-chloro-cyclic adenosine monophosphate transforming growth factor alpha Rattus norvegicus
14 These effects of 8-Cl-cAMP were linked to the cAMP analog"s selective modulation of the type I and type II cAMP-dependent protein kinase regulatory subunits, RI and RII, present in Ki-ras-transformed and TGF alpha-treated NRK cells. 8-chloro-cyclic adenosine monophosphate KRAS proto-oncogene, GTPase Rattus norvegicus
15 These effects of 8-Cl-cAMP were linked to the cAMP analog"s selective modulation of the type I and type II cAMP-dependent protein kinase regulatory subunits, RI and RII, present in Ki-ras-transformed and TGF alpha-treated NRK cells. 8-chloro-cyclic adenosine monophosphate transforming growth factor alpha Rattus norvegicus
16 These effects of 8-Cl-cAMP were linked to the cAMP analog"s selective modulation of the type I and type II cAMP-dependent protein kinase regulatory subunits, RI and RII, present in Ki-ras-transformed and TGF alpha-treated NRK cells. 8-chloro-cyclic adenosine monophosphate KRAS proto-oncogene, GTPase Rattus norvegicus
17 These effects of 8-Cl-cAMP were linked to the cAMP analog"s selective modulation of the type I and type II cAMP-dependent protein kinase regulatory subunits, RI and RII, present in Ki-ras-transformed and TGF alpha-treated NRK cells. 8-chloro-cyclic adenosine monophosphate transforming growth factor alpha Rattus norvegicus