Pub. Date : 2014
PMID : 25203114
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Moreover, external ROS (H2O2 100 microM, 24 h) rescued the effects of NOX4 knockdown, which included the declining of TRPC1 and 6 expression, basal intracellular calcium concentration ([Ca2+]i) and store-operated calcium entry (SOCE), suggesting that NOX4 plays as an important mediator in BMP4-induced proliferation and intracellular calcium homeostasis. | Reactive Oxygen Species | bone morphogenetic protein 4 | Rattus norvegicus |
| 2 | Moreover, external ROS (H2O2 100 microM, 24 h) rescued the effects of NOX4 knockdown, which included the declining of TRPC1 and 6 expression, basal intracellular calcium concentration ([Ca2+]i) and store-operated calcium entry (SOCE), suggesting that NOX4 plays as an important mediator in BMP4-induced proliferation and intracellular calcium homeostasis. | Hydrogen Peroxide | bone morphogenetic protein 4 | Rattus norvegicus |
| 3 | CONCLUSION: These results suggest that BMP4 may increase ROS level, enhance TRPC1 and 6 expression and proliferation by up-regulating NOX4 expression in PASMCs. | Reactive Oxygen Species | bone morphogenetic protein 4 | Rattus norvegicus |
| 4 | CONCLUSION: These results suggest that BMP4 may increase ROS level, enhance TRPC1 and 6 expression and proliferation by up-regulating NOX4 expression in PASMCs. | pasmcs | bone morphogenetic protein 4 | Rattus norvegicus |