Title : Retrotransposition of long interspersed element 1 induced by methamphetamine or cocaine.

Pub. Date : 2014 Sep 12

PMID : 25053411






9 Functional Relationships(s)
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1 The aim of this study was to identify the mechanism and effects of methamphetamine (METH) and cocaine on L1-RTP. Methamphetamine MORN repeat containing 4 Homo sapiens
2 The aim of this study was to identify the mechanism and effects of methamphetamine (METH) and cocaine on L1-RTP. Methamphetamine MORN repeat containing 4 Homo sapiens
3 The aim of this study was to identify the mechanism and effects of methamphetamine (METH) and cocaine on L1-RTP. Cocaine MORN repeat containing 4 Homo sapiens
4 Our results revealed that METH and cocaine induced L1-RTP in neuronal cell lines. Methamphetamine MORN repeat containing 4 Homo sapiens
5 Our results revealed that METH and cocaine induced L1-RTP in neuronal cell lines. Cocaine MORN repeat containing 4 Homo sapiens
6 RNA interference experiments combined with add-back of siRNA-resistant cDNAs revealed that the induction of L1-RTP by METH or cocaine depends on the activation of cAMP response element-binding protein (CREB). Methamphetamine MORN repeat containing 4 Homo sapiens
7 RNA interference experiments combined with add-back of siRNA-resistant cDNAs revealed that the induction of L1-RTP by METH or cocaine depends on the activation of cAMP response element-binding protein (CREB). Cocaine MORN repeat containing 4 Homo sapiens
8 These data suggest that the cellular cascades underlying METH- and cocaine-induced L1-RTP are different from those behind L1-RTP triggered by DNA damage; CREB is involved in drug-induced L1-RTP. Methamphetamine MORN repeat containing 4 Homo sapiens
9 These data suggest that the cellular cascades underlying METH- and cocaine-induced L1-RTP are different from those behind L1-RTP triggered by DNA damage; CREB is involved in drug-induced L1-RTP. Cocaine MORN repeat containing 4 Homo sapiens