Pub. Date : 2014 Jul 17
PMID : 25032863
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that hydrogen peroxide (H2O2) promotes PML deacetylation and identified SIRT1 and SIRT5 as PML deacetylases. | Hydrogen Peroxide | sirtuin 5 | Homo sapiens |
| 2 | Both SIRT1 and SIRT5 are required for H2O2-mediated deacetylation of PML and accumulation of nuclear PML protein in HeLa cells. | Hydrogen Peroxide | sirtuin 5 | Homo sapiens |
| 3 | Furthermore, ectopic expression of wild-type SIRT5 but not a catalytic defective mutant can also restore H2O2-induced cell death in SIRT1 knockdown cells. | Hydrogen Peroxide | sirtuin 5 | Homo sapiens |