Pub. Date : 2014 Jul 15
PMID : 25025465
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PAFR is a G-protein coupled receptor which can be engaged and activated by phosphorylcholine residues on the lipooligosaccharide (LOS) of nontypeable Haemophilus influenzae and the teichoic acid of Streptococcus pneumoniae as well as by its natural ligand, platelet activating factor (PAF). | lipid-linked oligosaccharides | platelet activating factor receptor | Homo sapiens |
| 2 | PAFR is a G-protein coupled receptor which can be engaged and activated by phosphorylcholine residues on the lipooligosaccharide (LOS) of nontypeable Haemophilus influenzae and the teichoic acid of Streptococcus pneumoniae as well as by its natural ligand, platelet activating factor (PAF). | Teichoic Acids | platelet activating factor receptor | Homo sapiens |
| 3 | PAF receptor antagonists prevented LOS or PAF-assisted DsiRNA silencing, demonstrating that ligand engagement of PAFR is essential for this process. | Platelet Activating Factor | platelet activating factor receptor | Homo sapiens |
| 4 | Treatment with spiperone, a small molecule identified using the Connectivity map database to correlate gene expression changes in response to drug treatment with those associated with PAFR stimulation, also induced silencing. | Spiperone | platelet activating factor receptor | Homo sapiens |