Pub. Date : 2014 Sep
PMID : 24926821
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The majority of human PCas express a transmembrane protease serine 2 (TMPRSS2):erythroblast transformation-specific (ETS) fusion gene, but most preclinical studies have been performed in PCa models lacking TMPRSS2:ETS in part due to the limited availability of model systems expressing endogenous TMPRSS2:ETS. | ets | transmembrane serine protease 2 | Homo sapiens |
| 2 | In TMPRSS2:ETS positive VCaP cells, depletion of TMPRSS2:ETS substantially reduced 1,25D-mediated CYP24A1 induction. | ets | transmembrane serine protease 2 | Homo sapiens |
| 3 | In TMPRSS2:ETS positive VCaP cells, depletion of TMPRSS2:ETS substantially reduced 1,25D-mediated CYP24A1 induction. | ets | transmembrane serine protease 2 | Homo sapiens |
| 4 | In TMPRSS2:ETS positive VCaP cells, depletion of TMPRSS2:ETS substantially reduced 1,25D-mediated CYP24A1 induction. | ets | transmembrane serine protease 2 | Homo sapiens |
| 5 | In TMPRSS2:ETS positive VCaP cells, depletion of TMPRSS2:ETS substantially reduced 1,25D-mediated CYP24A1 induction. | ets | transmembrane serine protease 2 | Homo sapiens |
| 6 | Artificial expression of the type VI+72 TMPRSS2:ETS isoform in LNCaP cells synergized with 1,25D to greatly increase CYP24A1 expression. | ets | transmembrane serine protease 2 | Homo sapiens |
| 7 | Our findings suggest that patients with TMPRSS2:ETS negative tumors may be more responsive to VDR-mediated growth inhibition and that TMPRSS2:ETS status should be considered in future clinical trials. | ets | transmembrane serine protease 2 | Homo sapiens |
| 8 | Our findings suggest that patients with TMPRSS2:ETS negative tumors may be more responsive to VDR-mediated growth inhibition and that TMPRSS2:ETS status should be considered in future clinical trials. | ets | transmembrane serine protease 2 | Homo sapiens |