Title : Polyunsaturated fatty acids inhibit stimulated coupling between the ER Ca(2+) sensor STIM1 and the Ca(2+) channel protein Orai1 in a process that correlates with inhibition of stimulated STIM1 oligomerization.

Pub. Date : 2014 Aug

PMID : 24769339






3 Functional Relationships(s)
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1 Polyunsaturated fatty acids (PUFAs) have been found to be effective inhibitors of cell signaling in numerous contexts, and we find that acute addition of micromolar PUFAs such as linoleic acid effectively inhibit of Ca(2+) responses in mast cells stimulated by antigen-mediated crosslinking of FcepsilonRI or by the SERCA pump inhibitor, thapsigargin. Fatty Acids, Unsaturated Fc epsilon receptor Ia Homo sapiens
2 Polyunsaturated fatty acids (PUFAs) have been found to be effective inhibitors of cell signaling in numerous contexts, and we find that acute addition of micromolar PUFAs such as linoleic acid effectively inhibit of Ca(2+) responses in mast cells stimulated by antigen-mediated crosslinking of FcepsilonRI or by the SERCA pump inhibitor, thapsigargin. Fatty Acids, Unsaturated Fc epsilon receptor Ia Homo sapiens
3 Polyunsaturated fatty acids (PUFAs) have been found to be effective inhibitors of cell signaling in numerous contexts, and we find that acute addition of micromolar PUFAs such as linoleic acid effectively inhibit of Ca(2+) responses in mast cells stimulated by antigen-mediated crosslinking of FcepsilonRI or by the SERCA pump inhibitor, thapsigargin. Linoleic Acid Fc epsilon receptor Ia Homo sapiens