Title : An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.

Pub. Date : 2014 Apr

PMID : 24584072






1 Functional Relationships(s)
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1 The BRD4 inhibitor JQ1 downregulates expression of these targets and induces growth arrest and apoptosis in persister cells, at doses well tolerated by GSI-sensitive cells. 2-(5-Chlorothiophen-2-Yl)-N-[(3s)-1-(4-{2-[(Dimethylamino)methyl]-1h-Imidazol-1-Yl}-2-Fluorophenyl)-2-Oxopyrrolidin-3-Yl]ethanesulfonamide bromodomain containing 4 Homo sapiens