Title : 15-Deoxy-∆12,14-PGJ 2, by activating peroxisome proliferator-activated receptor-gamma, suppresses p22phox transcription to protect brain endothelial cells against hypoxia-induced apoptosis.

Pub. Date : 2014 Aug

PMID : 24352801






2 Functional Relationships(s)
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1 15-Deoxy- 12,14-PGJ 2, by activating peroxisome proliferator-activated receptor-gamma, suppresses p22phox transcription to protect brain endothelial cells against hypoxia-induced apoptosis. 15-deoxy- 12,14-pgj 2 cytochrome b-245 alpha chain Homo sapiens
2 In summary, we report a novel transrepression mechanism whereby PPAR-gamma downregulates hypoxia-activated p22phox transcription and the subsequent NADPH oxidase activation, ROS formation, and CEC apoptosis. Reactive Oxygen Species cytochrome b-245 alpha chain Homo sapiens