Pub. Date : 2014
PMID : 24107596
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol inhibits hydrogen peroxide-induced apoptosis in endothelial cells via the activation of PI3K/Akt by miR-126. | Resveratrol | microRNA 126 | Homo sapiens |
| 2 | Resveratrol inhibits hydrogen peroxide-induced apoptosis in endothelial cells via the activation of PI3K/Akt by miR-126. | Hydrogen Peroxide | microRNA 126 | Homo sapiens |
| 3 | Real-time PCR was used to determine the microRNA-126(miR-126) expression in cells treated with RSV and/or H2O2. | Hydrogen Peroxide | microRNA 126 | Homo sapiens |
| 4 | We also found that H2O2 significantly suppressed the expression of miR-126, which was reversed by RSV in a dose-dependent manner. | Hydrogen Peroxide | microRNA 126 | Homo sapiens |
| 5 | The overexpression of miR-126 decreased PIK3R2(p85-beta) and enhanced Akt phosphorylation, which resulted in an increase in the survival of CRL-1730 cells exposed to H2O2. | Hydrogen Peroxide | microRNA 126 | Homo sapiens |
| 6 | More importantly, the downregulation of the miR-126 expression reversed the effects of RSV on the survival and apoptosis of CRL-1730 cells exposed to H2O2. | Hydrogen Peroxide | microRNA 126 | Homo sapiens |
| 7 | In addition, the knockdown of Ets-1 reversed the effects of RSV on the miR-126 expression in CRL-1730 cells exposed to H2O2. | Hydrogen Peroxide | microRNA 126 | Homo sapiens |