Title : Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence.

Pub. Date : 2014 Jul

PMID : 23727633






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 METHODS: Features of senescence (beta-galactosidase activity at pH 6 (SA-beta-gal) and active mammalian/mechanistic target of rapamycin (mTOR) in cell cycle arrest) as well as the activity of the two main pathways leading to cell senescence were examined in glucocorticoid-treated primary human tenocytes. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid galactosidase beta 1 Homo sapiens