Pub. Date : 2013
PMID : 23437250
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The expression levels of miR-126&126* were elevated in normal melanocytes and primary melanoma cell lines, whereas they markedly declined in metastatic cells. | Adenosine Monophosphate | microRNA 126 | Homo sapiens |
| 2 | Indeed, the restored expression of miR-126&126* in two advanced melanoma cell lines was accompanied by a significant reduction of proliferation, invasion and chemotaxis in vitro as well as of growth and dissemination in vivo. | Adenosine Monophosphate | microRNA 126 | Homo sapiens |
| 3 | In accordance, the reverse functional effects were obtained by knocking down miR-126&126* by transfecting antisense LNA oligonucleotides in melanoma cells. | Adenosine Monophosphate | microRNA 126 | Homo sapiens |
| 4 | In accordance, the reverse functional effects were obtained by knocking down miR-126&126* by transfecting antisense LNA oligonucleotides in melanoma cells. | Oligonucleotides | microRNA 126 | Homo sapiens |
| 5 | Finally, gene profile analyses showed that miR-126&126* reexpression was sufficient to inactivate other key signaling pathways involved in the oncogenic transformation, as PI3K/AKT and MAPK, and to restore melanogenesis, as indicated by KIT/MITF/TYR induction. | Adenosine Monophosphate | microRNA 126 | Homo sapiens |
| 6 | Finally, gene profile analyses showed that miR-126&126* reexpression was sufficient to inactivate other key signaling pathways involved in the oncogenic transformation, as PI3K/AKT and MAPK, and to restore melanogenesis, as indicated by KIT/MITF/TYR induction. | Tyrosine | microRNA 126 | Homo sapiens |
| 7 | In view of this miR-126&126* wide-ranging action, we believe that the replacement of these microRNAs might be considered a promising therapeutic approach. | Adenosine Monophosphate | microRNA 126 | Homo sapiens |