Pub. Date : 2013 Feb
PMID : 23218026
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Imatinib and Nilotinib inhibit Bcr-Abl-induced ROS through targeted degradation of the NADPH oxidase subunit p22phox. | Imatinib Mesylate | cytochrome b-245 alpha chain | Homo sapiens |
| 2 | Imatinib and Nilotinib inhibit Bcr-Abl-induced ROS through targeted degradation of the NADPH oxidase subunit p22phox. | nilotinib | cytochrome b-245 alpha chain | Homo sapiens |
| 3 | Imatinib and Nilotinib inhibit Bcr-Abl-induced ROS through targeted degradation of the NADPH oxidase subunit p22phox. | Reactive Oxygen Species | cytochrome b-245 alpha chain | Homo sapiens |
| 4 | In this study, using the K562 CML cell line we showed that inhibition of Bcr-Abl signalling, by either Imatinib or Nilotinib, led to a significant reduction in ROS levels which was concurrent with the GSK-3beta dependent, post-translational down-regulation of the small membrane-bound protein p22phox, an essential component of the Nox complex. | Imatinib Mesylate | cytochrome b-245 alpha chain | Homo sapiens |
| 5 | In this study, using the K562 CML cell line we showed that inhibition of Bcr-Abl signalling, by either Imatinib or Nilotinib, led to a significant reduction in ROS levels which was concurrent with the GSK-3beta dependent, post-translational down-regulation of the small membrane-bound protein p22phox, an essential component of the Nox complex. | nilotinib | cytochrome b-245 alpha chain | Homo sapiens |
| 6 | In this study, using the K562 CML cell line we showed that inhibition of Bcr-Abl signalling, by either Imatinib or Nilotinib, led to a significant reduction in ROS levels which was concurrent with the GSK-3beta dependent, post-translational down-regulation of the small membrane-bound protein p22phox, an essential component of the Nox complex. | Reactive Oxygen Species | cytochrome b-245 alpha chain | Homo sapiens |
| 7 | Furthermore, siRNA knockdown of p22phox in these cells established its importance in ROS production and proliferation. | Reactive Oxygen Species | cytochrome b-245 alpha chain | Homo sapiens |