Title : Integration of ERĪ±-PELP1-HER2 signaling by LSD1 (KDM1A/AOF2) offers combinatorial therapeutic opportunities to circumventing hormone resistance in breast cancer.

Pub. Date : 2012 Sep 17

PMID : 22992372






2 Functional Relationships(s)
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1 show, for the first time, that knockdown or drug-mediated inhibition of PELP1 or LSD1 suppresses LSD1-mediated transcriptionally activating histone marks at ERalpha target genes, inhibits aromatase gene expression, and sensitizes hormone refractory breast cancer cells to tamoxifen or letrozole treatments. Tamoxifen proline, glutamate and leucine rich protein 1 Homo sapiens
2 show, for the first time, that knockdown or drug-mediated inhibition of PELP1 or LSD1 suppresses LSD1-mediated transcriptionally activating histone marks at ERalpha target genes, inhibits aromatase gene expression, and sensitizes hormone refractory breast cancer cells to tamoxifen or letrozole treatments. Letrozole proline, glutamate and leucine rich protein 1 Homo sapiens