Title : Basis of miscoding of the DNA adduct N2,3-ethenoguanine by human Y-family DNA polymerases.

Pub. Date : 2012 Oct 12

PMID : 22910910






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Pol iota had the highest dTTP misincorporation frequency (0.71) followed by pol eta (0.63). thymidine 5'-triphosphate DNA polymerase mu Homo sapiens
2 REV1 misincorporated dTTP and dGTP with much lower frequencies. thymidine 5'-triphosphate REV1 DNA directed polymerase Homo sapiens
3 Crystal structures of pol iota with N(2),3-epsilonG paired to dCTP and dTTP revealed Hoogsteen-like base pairing mechanisms. thymidine 5'-triphosphate DNA polymerase mu Homo sapiens