Pub. Date : 2012
PMID : 22807997
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling. | Hydrogen Peroxide | cytochrome b-245 alpha chain | Homo sapiens |
| 2 | The majority of these ROS co-localize to the endoplasmic reticulum (ER), as determined with the H(2)O(2)-specific aryl-boronate dye Peroxyorange 1, which also corresponds to co-localization of p22phox. | Reactive Oxygen Species | cytochrome b-245 alpha chain | Homo sapiens |
| 3 | The majority of these ROS co-localize to the endoplasmic reticulum (ER), as determined with the H(2)O(2)-specific aryl-boronate dye Peroxyorange 1, which also corresponds to co-localization of p22phox. | aryl-boronate | cytochrome b-245 alpha chain | Homo sapiens |
| 4 | Thus, we have shown that FLT3 driven H(2)O(2) production in AML cells is mediated by p22phox and is critical for STAT5 signalling. | Hydrogen Peroxide | cytochrome b-245 alpha chain | Homo sapiens |