Title : Expression of PAFR as part of a prosurvival response to chemotherapy: a novel target for combination therapy in melanoma.

Pub. Date : 2012

PMID : 22570511






2 Functional Relationships(s)
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1 Melanoma cells express the platelet-activating factor receptor (PAFR) and, thus, respond to PAF, a bioactive lipid produced by both tumour cells and those in the tumour microenvironment such as macrophages. Platelet Activating Factor platelet activating factor receptor Homo sapiens
2 Here, we show that treatment of a human melanoma SKmel37 cell line with cisplatin led to increased expression of PAFR and its accumulation. Cisplatin platelet activating factor receptor Homo sapiens