Title : BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain.

Pub. Date : 2012 May 1

PMID : 22509028






1 Functional Relationships(s)
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1 We report that BRD4 is an atypical kinase that binds to the carboxyl-terminal domain (CTD) of RNA polymerase II and directly phosphorylates its serine 2 (Ser2) sites both in vitro and in vivo under conditions where other CTD kinases are inactive. serine 2 bromodomain containing 4 Homo sapiens