Title : Reduced collagen deposition in infarcted myocardium facilitates induced pluripotent stem cell engraftment and angiomyogenesis for improvement of left ventricular function.

Pub. Date : 2011 Nov 8

PMID : 22051336






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In vivo: A Tri-P was affixed over the entire infarcted area 7 days after myocardial infarction in mice overexpressing adenylyl cyclase 6 (AC6). tri-p adenylate cyclase 6 Mus musculus
2 In vivo: A Tri-P was affixed over the entire infarcted area 7 days after myocardial infarction in mice overexpressing adenylyl cyclase 6 (AC6). tri-p adenylate cyclase 6 Mus musculus
3 RESULTS: In AC6 mice, infarcted hearts treated with Tri-P showed significantly higher bioluminescence imaging intensity and numbers of green fluorescent protein-positive cells than in WT mice. tri-p adenylate cyclase 6 Mus musculus
4 CONCLUSIONS: Application of a Tri-P in AC6 mice resulted in significantly higher induced pluripotent stem cell engraftment accompanied by angiomyogenesis in the infarcted area and improvement in LV function. tri-p adenylate cyclase 6 Mus musculus