Pub. Date : 2011 Dec
PMID : 21993412
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production. | 4-cresol | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production. | 4-cresol | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | In this study, p-cresol (1-5 muM) inhibited the arachidonic acid (AA)-induced platelet aggregation, with 47% and 82% of inhibition at concentrations of 2 and 5 muM, respectively. | 4-cresol | latexin | Homo sapiens |
| 4 | In this study, p-cresol (1-5 muM) inhibited the arachidonic acid (AA)-induced platelet aggregation, with 47% and 82% of inhibition at concentrations of 2 and 5 muM, respectively. | 4-cresol | latexin | Homo sapiens |
| 5 | P-cresol (2-100 muM) partly inhibited the AA-induced reactive oxygen species (ROS) production as well as the extracellular signal-regulated kinase (ERK1/2) and p38 phosphorylation in platelets. | 4-cresol | latexin | Homo sapiens |
| 6 | P-cresol (2-100 muM) partly inhibited the AA-induced reactive oxygen species (ROS) production as well as the extracellular signal-regulated kinase (ERK1/2) and p38 phosphorylation in platelets. | 4-cresol | mitogen-activated protein kinase 3 | Homo sapiens |
| 7 | P-cresol (2-100 muM) partly inhibited the AA-induced reactive oxygen species (ROS) production as well as the extracellular signal-regulated kinase (ERK1/2) and p38 phosphorylation in platelets. | 4-cresol | mitogen-activated protein kinase 1 | Homo sapiens |
| 8 | P-cresol further inhibited the AA-induced aggregation of rabbit platelet-rich plasma (PRP) with an IC50 of 2 muM and aggregation of human PRP (IC50 = 13.6 muM). | 4-cresol | latexin | Homo sapiens |
| 9 | P-cresol further inhibited the AA-induced aggregation of rabbit platelet-rich plasma (PRP) with an IC50 of 2 muM and aggregation of human PRP (IC50 = 13.6 muM). | 4-cresol | latexin | Homo sapiens |
| 10 | Intravenous administration of p-cresol (250-1000 nmole) into mice effectively suppressed the ex vivo platelet aggregation, whereas showed little effect on the value of RBC, hemoglobin (HGB), hematocrit, MCV, MCH, MCHC, platelets and lymphocyte counts. | 4-cresol | modifier of chinchilla | Mus musculus |
| 11 | These results indicate that in acute p-cresol-poisoning and long-term exposure to cresol as in severe uremic patients, p-cresol may potentially inhibit blood clot formation and lead to hemorrhagic disorders via inhibition of platelet aggregation, ROS production, ERK/p38 activation and TXA(2) production. | 4-cresol | mitogen-activated protein kinase 3 | Homo sapiens |
| 12 | These results indicate that in acute p-cresol-poisoning and long-term exposure to cresol as in severe uremic patients, p-cresol may potentially inhibit blood clot formation and lead to hemorrhagic disorders via inhibition of platelet aggregation, ROS production, ERK/p38 activation and TXA(2) production. | 4-cresol | mitogen-activated protein kinase 1 | Homo sapiens |