Title : Association of genetic variants in the promoter region of genes encoding p22phox (CYBA) and glutamate cysteine ligase catalytic subunit (GCLC) and renal disease in patients with type 1 diabetes mellitus.

Pub. Date : 2011 Sep 30

PMID : 21962117






3 Functional Relationships(s)
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Protein Name
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1 NOX/NADPH oxidases generate reactive oxygen species and NOX1, NOX2 and NOX4 isoforms are expressed in kidney and require association with subunit p22phox (encoded by the CYBA gene). Reactive Oxygen Species cytochrome b-245 alpha chain Homo sapiens
2 NOX/NADPH oxidases generate reactive oxygen species and NOX1, NOX2 and NOX4 isoforms are expressed in kidney and require association with subunit p22phox (encoded by the CYBA gene). Reactive Oxygen Species cytochrome b-245 alpha chain Homo sapiens
3 The aim of the present investigation was to test whether functional single nucleotide polymorphisms (SNPs) in genes involved in the generation of NADPH-dependent O2 - (-675 T A in CYBA, unregistered) and in glutathione metabolism (-129 C T in GCLC [rs17883901] and -65 T C in GPX3 [rs8177412]) confer susceptibility to renal disease in type 1 diabetes patients. NADP cytochrome b-245 alpha chain Homo sapiens