Title : Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation.

Pub. Date : 2011 Dec

PMID : 21890894






3 Functional Relationships(s)
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1 Here, by analyzing the dynamics of Brd4 during ultraviolet or hexamethylene bisacetamide treatment, we show that the signal-induced release of chromatin-bound Brd4 is essential for its functional transition. hexamethylene bisacetamide bromodomain containing 4 Homo sapiens
2 Here, by analyzing the dynamics of Brd4 during ultraviolet or hexamethylene bisacetamide treatment, we show that the signal-induced release of chromatin-bound Brd4 is essential for its functional transition. hexamethylene bisacetamide bromodomain containing 4 Homo sapiens
3 Upon treatment, Brd4 is released from chromatin, mostly due to signal-triggered deacetylation of nucleosomal histone H4 at acetylated-lysine 5/8 (H4K5ac/K8ac). acetylated-lysine bromodomain containing 4 Homo sapiens