Title : Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors.

Pub. Date : 2011 Oct 1

PMID : 21807619






2 Functional Relationships(s)
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1 In isolated rat ventricular myocytes, the CG digitoxin (DGT) increased the incidence of arrhythmogenic spontaneous Ca(2+) waves, decreased the sarcoplasmic reticulum (SR) Ca(2+) load, and increased both ROS and RyR2 thiol oxidation. Digitoxin ryanodine receptor 2 Rattus norvegicus
2 In isolated rat ventricular myocytes, the CG digitoxin (DGT) increased the incidence of arrhythmogenic spontaneous Ca(2+) waves, decreased the sarcoplasmic reticulum (SR) Ca(2+) load, and increased both ROS and RyR2 thiol oxidation. Digitoxin ryanodine receptor 2 Rattus norvegicus