Title : Factors regulating the expression of acetylcholinesterase-containing neurons in striatal cultures: effects of chemical depolarization.

Pub. Date : 1990 Nov 5

PMID : 2178031






3 Functional Relationships(s)
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1 Chronic application of 5 microM veratridine resulted in a significant loss of neurites by AChE-positive cells, while a higher concentration (20 microM) reduced the number of stained cell bodies. Veratridine acetylcholinesterase Rattus norvegicus
2 Similarly, elevation of extracellular KCl levels (20-60 mM) produced a dose-dependent neurite loss by AChE-containing cells. Potassium Chloride acetylcholinesterase Rattus norvegicus
3 When cultures treated with 5 microM veratridine were allowed to recuperate for several days, the number of AChE-positive cells possessing neurites returned close to control values, thus indicating the reversibility of the effect of chemical depolarization. Veratridine acetylcholinesterase Rattus norvegicus