Title : Role of the carbohydrate residues of human chorionic gonadotropin in binding and stimulation of adenosine 3',5'-monophosphate accumulation by porcine granulosa cells.

Pub. Date : 1978 Aug

PMID : 217642






5 Functional Relationships(s)
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1 Removal of the sugar residues internal to sialic acid from the hCG molecule markedly diminished the ability of hCG to stimulate cAMP accumulation by porcine granulosa cells during a 30-min incubation period. N-Acetylneuraminic Acid hypertrichosis 2 (generalised, congenital) Homo sapiens
2 Removal of the sugar residues internal to sialic acid from the hCG molecule markedly diminished the ability of hCG to stimulate cAMP accumulation by porcine granulosa cells during a 30-min incubation period. N-Acetylneuraminic Acid hypertrichosis 2 (generalised, congenital) Homo sapiens
3 At the same time, removal of sugars internal to sialic acid enabled the resulting hCG derivatives to become competitive inhibitors of hCG stimulation of cAMP accumulation. N-Acetylneuraminic Acid hypertrichosis 2 (generalised, congenital) Homo sapiens
4 At the same time, removal of sugars internal to sialic acid enabled the resulting hCG derivatives to become competitive inhibitors of hCG stimulation of cAMP accumulation. N-Acetylneuraminic Acid hypertrichosis 2 (generalised, congenital) Homo sapiens
5 It would, therefore, seem that hCG with sugars internal to sialic acid removed is able to bind to the receptor, but that, once bound, it is unable to activate adenylate cyclase. N-Acetylneuraminic Acid hypertrichosis 2 (generalised, congenital) Homo sapiens