Title : Properties of monocyte chemotactic and activating factor (MCAF) purified from a human fibrosarcoma cell line.

Pub. Date : 1990 Jun 1

PMID : 2161898






4 Functional Relationships(s)
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Protein Name
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1 The purified MCAF showed microheterogeneity yielding two bands on SDS-PAGE analysis. Sodium Dodecyl Sulfate C-C motif chemokine ligand 2 Homo sapiens
2 Fibrosarcoma-derived MCAF specifically competed with THP-1 (a human monocytic cell line)-derived 125I-labeled MCAF in binding to human PBMC, whereas a similar basic heparin-binding leukocyte chemoattractant, IL-8, did not. Iodine-125 C-C motif chemokine ligand 2 Homo sapiens
3 Fibrosarcoma-derived MCAF specifically competed with THP-1 (a human monocytic cell line)-derived 125I-labeled MCAF in binding to human PBMC, whereas a similar basic heparin-binding leukocyte chemoattractant, IL-8, did not. Iodine-125 C-C motif chemokine ligand 2 Homo sapiens
4 The purified MCAF stimulated superoxide anion and N-acetyl beta-D glucosaminidase-releasing activity in human monocytes, as well as monocyte cytostatic augmenting activity against tumor cells and chemotactic activity for monocytes. Superoxides C-C motif chemokine ligand 2 Homo sapiens