Pub. Date : 1990 Jun
PMID : 2161750
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | At low concentrations (10-100 pg/ml) TGF beta enhanced 1,25-dihydroxyvitamin D3-dependent production of osteoclast-like cells, while at higher concentrations TGF beta was inhibitory. | Calcitriol | transforming growth factor, beta 1 | Mus musculus |
| 2 | Antibodies directed against TGF beta significantly reduced the generation of osteoclast-like cells in 1,25-dihydroxyvitamin D3-treated cultures, indicating the contribution of endogenous TGF beta activity. | Calcitriol | transforming growth factor, beta 1 | Mus musculus |
| 3 | Antibodies directed against TGF beta significantly reduced the generation of osteoclast-like cells in 1,25-dihydroxyvitamin D3-treated cultures, indicating the contribution of endogenous TGF beta activity. | Calcitriol | transforming growth factor, beta 1 | Mus musculus |
| 4 | TGF beta also enhanced the accumulation of prostaglandin E2 (PGE2) in a dose-dependent manner. | Dinoprostone | transforming growth factor, beta 1 | Mus musculus |
| 5 | TGF beta also enhanced the accumulation of prostaglandin E2 (PGE2) in a dose-dependent manner. | Dinoprostone | transforming growth factor, beta 1 | Mus musculus |
| 6 | It is, thus, suggested that PG activity, probably PGE2, mediates the enhancing effect of low TGF beta concentrations and is required for the generation of osteoclast-like cells in this system. | Prostaglandins | transforming growth factor, beta 1 | Mus musculus |
| 7 | It is, thus, suggested that PG activity, probably PGE2, mediates the enhancing effect of low TGF beta concentrations and is required for the generation of osteoclast-like cells in this system. | Dinoprostone | transforming growth factor, beta 1 | Mus musculus |