Pub. Date : 2011 Apr 15
PMID : 21421858
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we examined whether the nuclear receptor coregulator PELP1 (proline-, glutamic acid-, leucine-rich protein-1) contributes to progression and metastatic potential of ovarian cancer cells and determined whether blocking of the PELP1 signaling axis had a therapeutic effect. | Proline | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 2 | Therapeutic potential of PELP1-siRNA in vivo was determined using a nanoliposomal formulation of PELP1-siRNA-DOPC (1,2-dioleoyl-sn-glycero-3-phosphatidylcholine) administered systemically in a xenograft model. | 1,2-oleoylphosphatidylcholine | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 3 | Therapeutic potential of PELP1-siRNA in vivo was determined using a nanoliposomal formulation of PELP1-siRNA-DOPC (1,2-dioleoyl-sn-glycero-3-phosphatidylcholine) administered systemically in a xenograft model. | 1,2-oleoylphosphatidylcholine | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 4 | Therapeutic potential of PELP1-siRNA in vivo was determined using a nanoliposomal formulation of PELP1-siRNA-DOPC (1,2-dioleoyl-sn-glycero-3-phosphatidylcholine) administered systemically in a xenograft model. | 1,2-oleoylphosphatidylcholine | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 5 | Therapeutic potential of PELP1-siRNA in vivo was determined using a nanoliposomal formulation of PELP1-siRNA-DOPC (1,2-dioleoyl-sn-glycero-3-phosphatidylcholine) administered systemically in a xenograft model. | 1,2-oleoylphosphatidylcholine | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 6 | CONCLUSION: The results suggest that PELP1 signaling axis is a potential druggable target and liposomal PELP1-siRNA-DOPC could be used as a novel drug to prevent or treat ovarian metastasis. | 1,2-oleoylphosphatidylcholine | proline, glutamate and leucine rich protein 1 | Homo sapiens |