Pub. Date : 2011 Nov
PMID : 21184269
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pharmacological inhibition of Src using dasatinib, an orally available inhibitor substantially inhibited the growth of therapy resistant MCF7-PELP1, MCF7-HER2, and MCF7-Tam model cells in proliferation assays. | Dasatinib | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 2 | Combinatorial therapy of tamoxifen with dasatinib showed better therapeutic effect compared to single agent therapy on the growth of therapy resistant PELP1 driven tumors. | Tamoxifen | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 3 | Combinatorial therapy of tamoxifen with dasatinib showed better therapeutic effect compared to single agent therapy on the growth of therapy resistant PELP1 driven tumors. | Dasatinib | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 4 | Since PELP1, HER2, and Src kinase are commonly deregulated in breast cancers, combination therapies using both endocrine agents and dasatinib may have better therapeutic effect by delaying the development of hormonal resistance. | Dasatinib | proline, glutamate and leucine rich protein 1 | Homo sapiens |