Title : Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

Pub. Date : 1990 Aug 1

PMID : 2115549






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Macrophage deactivating factor (MDF) and three members of the transforming growth factor-beta family (TGF-beta 1, -beta 2, and -beta 3) blocked the ability of IFN-gamma to induce release of reactive nitrogen intermediates from mouse peritoneal macrophages. reactive nitrogen intermediates transforming growth factor, beta 1 Mus musculus
2 MDF and TGF-beta 1, -beta 2, and -beta 3 inhibited IFN-gamma-induced nitrite release only if present during the induction phase; once IFN-gamma-nitrite release had commenced, addition of the same cytokines was no longer inhibitory. Nitrites transforming growth factor, beta 1 Mus musculus