Pub. Date : 2010 Nov 18
PMID : 21139994
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Digitoxin activates EGR1 and synergizes with paclitaxel on human breast cancer cells. | Digitoxin | early growth response 1 | Homo sapiens |
| 2 | In the present study, we have used gene expression analysis to determine the molecular action of digitoxin on breast cancer cells and assessed digitoxin"s ability to synergize with the chemotherapy agent paclitaxel with respect to inhibition of cell proliferation MATERIALS AND METHODS: We treated (Her2 overexpressing, ER low) MDA-MB-453 human breast cancer cells with digitoxin at four doses {20 ng/ml (26 nM) to 1 mug/ml} and collected RNA at 6 h and 24 h for gene expression analysis. | Digitoxin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 3 | In the present study, we have used gene expression analysis to determine the molecular action of digitoxin on breast cancer cells and assessed digitoxin"s ability to synergize with the chemotherapy agent paclitaxel with respect to inhibition of cell proliferation MATERIALS AND METHODS: We treated (Her2 overexpressing, ER low) MDA-MB-453 human breast cancer cells with digitoxin at four doses {20 ng/ml (26 nM) to 1 mug/ml} and collected RNA at 6 h and 24 h for gene expression analysis. | Digitoxin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 4 | RESULTS: To reveal primary effects, we examined digitoxin"s effect 6 h post-treatment with the highest dose, 1mug/ml, and found upregulation of the stress response genes EGR-1 and NAB2, lipid biosynthetic genes and the tumor suppressor gene p21, and downregulation of the mitotic cell cycle gene CDC16 and the replication gene PolR3B. | Digitoxin | early growth response 1 | Homo sapiens |
| 5 | RESULTS: To reveal primary effects, we examined digitoxin"s effect 6 h post-treatment with the highest dose, 1mug/ml, and found upregulation of the stress response genes EGR-1 and NAB2, lipid biosynthetic genes and the tumor suppressor gene p21, and downregulation of the mitotic cell cycle gene CDC16 and the replication gene PolR3B. | Digitoxin | NGFI-A binding protein 2 | Homo sapiens |
| 6 | RESULTS: To reveal primary effects, we examined digitoxin"s effect 6 h post-treatment with the highest dose, 1mug/ml, and found upregulation of the stress response genes EGR-1 and NAB2, lipid biosynthetic genes and the tumor suppressor gene p21, and downregulation of the mitotic cell cycle gene CDC16 and the replication gene PolR3B. | Digitoxin | H3 histone pseudogene 16 | Homo sapiens |
| 7 | RESULTS: To reveal primary effects, we examined digitoxin"s effect 6 h post-treatment with the highest dose, 1mug/ml, and found upregulation of the stress response genes EGR-1 and NAB2, lipid biosynthetic genes and the tumor suppressor gene p21, and downregulation of the mitotic cell cycle gene CDC16 and the replication gene PolR3B. | Digitoxin | cell division cycle 16 | Homo sapiens |
| 8 | RESULTS: To reveal primary effects, we examined digitoxin"s effect 6 h post-treatment with the highest dose, 1mug/ml, and found upregulation of the stress response genes EGR-1 and NAB2, lipid biosynthetic genes and the tumor suppressor gene p21, and downregulation of the mitotic cell cycle gene CDC16 and the replication gene PolR3B. | Digitoxin | RNA polymerase III subunit B | Homo sapiens |