Title : Biotransformation of N,N',N''-triethylenethiophosphoramide: oxidative desulfuration to yield N,N',N''-triethylenephosphoramide associated with suicide inactivation of a phenobarbital-inducible hepatic P-450 monooxygenase.

Pub. Date : 1990 Feb 1

PMID : 2105156






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Oxidative metabolism of the polyfunctional alkylating agent N,N",N""-triethylenethiophosphoramide (thio-TEPA) was studied in isolated rat liver microsomes and purified, reconstituted cytochrome P-450 (P-450) enzyme systems in order to elucidate the pathways of drug oxidation and to identify the possible contributions of individual P-450 enzymes to the bioactivation of this chemotherapeutic agent. Thiotepa cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus