Pub. Date : 1991 May
PMID : 2068954
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In resorbing calvariae and long bones with an established marrow cavity TGF-beta 1 (4-10 ng/ml) had a stimulating effect on 45Ca release that was partially inhibited by indomethacin. | Indomethacin | transforming growth factor, beta 1 | Mus musculus |
| 2 | In primitive long bones, however, which were explanted before osteoclast invasion and excavation of a marrow cavity had started, TGF-beta 1 (1-4 ng/ml) inhibited 45Ca release by an indomethacin-insensitive mechanism. | Indomethacin | transforming growth factor, beta 1 | Mus musculus |
| 3 | These data suggest that TGF-beta 1 modulates various steps in the cascade of osteoclast development, recruitment, and activation in different ways, involving both prostaglandin-mediated and prostaglandin-independent pathways. | Prostaglandins | transforming growth factor, beta 1 | Mus musculus |
| 4 | These data suggest that TGF-beta 1 modulates various steps in the cascade of osteoclast development, recruitment, and activation in different ways, involving both prostaglandin-mediated and prostaglandin-independent pathways. | Prostaglandins | transforming growth factor, beta 1 | Mus musculus |