Title : Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements.

Pub. Date : 2010 Aug

PMID : 20601956






1 Functional Relationships(s)
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1 We show that androgen signaling promotes co-recruitment of androgen receptor and topoisomerase II beta (TOP2B) to sites of TMPRSS2-ERG genomic breakpoints, triggering recombinogenic TOP2B-mediated DSBs. dsbs transmembrane serine protease 2 Homo sapiens