Title : The effect of mitomycin C on platelet aggregation and adenosine 3',5'-monophosphate metabolism.

Pub. Date : 1978 Feb 28

PMID : 205972






3 Functional Relationships(s)
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1 The effect of Mitomycin C on aggregation, adenosine 3",5"-monophosphate (cyclic AMP) metabolism and reactions induced by thrombin was studied in rabbit platelets. Mitomycin prothrombin Oryctolagus cuniculus
2 Mitomycin C inhibited the platelet aggregation induced by adenosine diphosphate or thrombin. Mitomycin prothrombin Oryctolagus cuniculus
3 In the platelets preincubated with Mitomycin C, thrombin-induced inhibition of adenyl cyclase, stimulation of membrane-bound cyclic AMP phosphodiesterase, and release of 250,000 dalton protein from platelet membranes were prevented. Mitomycin prothrombin Oryctolagus cuniculus