Title : On the mechanism of the acceleration of methanesulfonylation of acetylcholinesterase with cationic accelerators.

Pub. Date : 1978 Mar 14

PMID : 204352






4 Functional Relationships(s)
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1 In order to elucidate some features of the mechanism of the acceleration of methanesulfonylation of acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) with cationic accelerators, the methanesulfonylation of this enzyme by high concentrations of methanesulfonylfluoride, in the absence and presence of accelerators decamethonium and tetraethylammonium, was studied. methanesulfonyl fluoride acetylcholinesterase (Cartwright blood group) Homo sapiens
2 In order to elucidate some features of the mechanism of the acceleration of methanesulfonylation of acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) with cationic accelerators, the methanesulfonylation of this enzyme by high concentrations of methanesulfonylfluoride, in the absence and presence of accelerators decamethonium and tetraethylammonium, was studied. decamethonium acetylcholinesterase (Cartwright blood group) Homo sapiens
3 In order to elucidate some features of the mechanism of the acceleration of methanesulfonylation of acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) with cationic accelerators, the methanesulfonylation of this enzyme by high concentrations of methanesulfonylfluoride, in the absence and presence of accelerators decamethonium and tetraethylammonium, was studied. Tetraethylammonium acetylcholinesterase (Cartwright blood group) Homo sapiens
4 The results showed that the accelerator accelerates the reaction by electrostatically improving the binding between acetylcholinesterase and methanesulfonylfluoride without effecting the rate of the decomposition of the enzyme-inhibitor complex into the methanesulfonylated enzyme and product. methanesulfonyl fluoride acetylcholinesterase (Cartwright blood group) Homo sapiens