Title : Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells.

Pub. Date : 2011 Feb

PMID : 20354780






2 Functional Relationships(s)
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1 In this study, we have used the novel FAK inhibitor PF573228 to address the role of FAK in the development of endocrine resistance. 6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one protein tyrosine kinase 2 Homo sapiens
2 PF573228 promoted a dose-dependent inhibition of FAK phosphorylation at Y397 but did not affect other FAK activation sites (pY407, pY576 and pY861). 6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one protein tyrosine kinase 2 Homo sapiens