Title : Gamma-glutamyl transpeptidase null mice fail to develop tolerance to coumarin-induced Clara cell toxicity.

Pub. Date : 2010 Jun

PMID : 20347914






2 Functional Relationships(s)
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1 After one dose of coumarin, CC10 expression was dramatically reduced and the bronchiolar epithelium was devoid of Clara cells in GGT(+/+) and GGT(-/-) mice. coumarin secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus
2 In wildtype mice, 9 doses of coumarin produced tolerance, characterized as a renewed bronchiolar epithelium with Clara cells expressing CC10 along with a 40% increase in total glutathione (GSH) and a 7-fold increase in GGT activity in the lung. coumarin secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus