Title : Determination of basal acetylcholine release in vivo by rat brain dialysis with a U-shaped cannula: effect of SM-10888, a putative therapeutic drug for Alzheimer's disease.

Pub. Date : 1991 Feb 25

PMID : 2027531






1 Functional Relationships(s)
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1 When SM-10888, a novel AChE inhibitor and putative therapeutic drug for Alzheimer"s disease, was injected intraperitoneally, ACh in the dialysate of the cortex increased in a dose-dependent manner. 9-amino-8-fluoro-1,2,3,4-tetrahydro-2,4-methanoacridine acetylcholinesterase Rattus norvegicus