Title : Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1.

Pub. Date : 2010 Feb 15

PMID : 20103533






4 Functional Relationships(s)
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1 Introduction of Mfn1(T109A), a GTPase-deficient mutant form of Mfn1, into MARCH5-RNAi cells not only disrupted mitochondrial elongation, but also abolished the increase in SA-beta-Gal activity. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid mitofusin 1 Homo sapiens
2 Introduction of Mfn1(T109A), a GTPase-deficient mutant form of Mfn1, into MARCH5-RNAi cells not only disrupted mitochondrial elongation, but also abolished the increase in SA-beta-Gal activity. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid mitofusin 1 Homo sapiens
3 Moreover, the aberrant mitochondrial phenotypes in MARCH5-RNAi cells were reversed by ectopic expression of Drp1, but not by hFis1, and reversion of the mitochondria morphology in MARCH5-depleted cells was accompanied by a reduction in SA-beta-Gal activity. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid membrane associated ring-CH-type finger 5 Homo sapiens
4 Moreover, the aberrant mitochondrial phenotypes in MARCH5-RNAi cells were reversed by ectopic expression of Drp1, but not by hFis1, and reversion of the mitochondria morphology in MARCH5-depleted cells was accompanied by a reduction in SA-beta-Gal activity. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid membrane associated ring-CH-type finger 5 Homo sapiens